ImmunoMap: A Bioinformatics Tool for T-cell Repertoire Analysis

Overview of methodologies for T-cell receptor repertoire analysis

BACKGROUND The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response. Analysing the TCR repertoire may help to gain a better understanding of the immune system features and of the aetiology and progression of diseases, in particular those with unknown ant...

A Truncated T Cell Receptor Repertoire Reveals

Induction of T cell responses to an antigenic peptide that is known to bind a major histocompatibility complex molecule is a function of either the T cell receptor (TCI<) repertoire or regulatory influences by CD8 or CD4 regulatory T cells. We have tested the hypothesis that a lack of 10 TC1L V~ gene segments in Vf3 a mice may result in an incomplete repertoire of regulatory T cells involved in...

Shaping the T cell repertoire.

IGoR: a tool for high-throughput immune repertoire analysis

High throughput immune repertoire sequencing is promising to lead to new statistical diagnostic tools for medicine and biology. Successful implementations of these methods require a correct characterization, analysis and interpretation of these datasets. We present IGoR – a new comprehensive tool that takes B or T-cell receptors sequence reads and quantitatively characterizes the statistics of ...

MaGiK method of T-Cell receptor repertoire analysis.

T-cell receptor diversity enables the cellular immune response to recognize a broad range of viral and other pathogenic agents. An increasingly common method of characterizing T-cell receptor diversity and usage in response to antigenic challenges involves the identification of clonal expansions by PCR amplification of the CDR3 region of distinct TCRVbeta families. Though clonal expansions ofte...